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Original Article

Med Arch. 2021; 75(6): 413-417


Population-genetic Aspects of Breast Cancers and Association with Rh Factor in Selected Sample

Azra Metovic, Jasmin Musanovic, Nerman Ramic, Orhan Lepara, Damir Secic, Esad Pepic, Svjetlana Loga Zec, Senad Sljuka.




Abstract

Background: Breast cancer in women is the second most common and accounts for approximately 18% of all malignant tumors in women worldwide. The etiology of breast cancer is not clear enough. Starting from the assumption that the manifestation of breast cancer may have a multifactorial model, this article compares the population-genetic structure of patients (experimental group) with the population-genetic structure of healthy population (control group). Objective: The aim of the study was to examine the possible genetic basis of the Rh factor relationship with selected homozygous-recessive traits of females with breast cancer, and to diagnose the probability (assess the risk) of developing the disease in healthy women by analyzing homozygous-recessive traits (HRT). Methods: This are an anthroposcopic-qualitative study that included two groups of subjects, experimental and control (a total of 80 subjects). An analysis of the percentages within each group was performed using the Chi-square test. The results are presented in tables, and the accepted level of significance is at the level of p

Key words: breast cancer, recessive trait, homozygous recessive, Rh factors.






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