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Technical Note

EJMCM. 2019; 6(1): 26-34

The mechanisms and challenges of cancer chemotherapy resistance: A current overview

Ravindran Ankathil.

Chemotherapy remains one of the principal modes of treatment for cancer patients. Despite
advances in anticancer agents for multiple cancers, development of resistance to classical
chemotherapeutic drugs and targeted drugs continues to be a major challenge. Drug resistance
which can be either intrinsic or acquired, leads to treatment failure and tumor progression. Drug
resistance occurs because of mechanisms that are associated with individual cancer cells or
through mechanisms that relate to the microenvironment within tumors. Multiple molecular
determinants of intrinsic and acquired resistance including genetic, epigenetic factors, as well
as other factors which act at the genomic or cellular level have been identified. This review
provides a conspectus on some of the recent discoveries on mechanisms of anticancer drug
resistance and the possible ways to revert resistance and thereby improve cancer therapy.

Key words: Chemotherapy,microenvironment within tumors

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