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Research Article

EJMCM. 2019; 6(1): 20-25


The role of oxidative stress on molybdenum enzymes and ischemic reperfusion injury in hyperuricaemic patients. An infrared spectroscopic study

Mamareli V, Tanis O, Anastassopoulou J, Kyriakidou M, Mamareli CH, Koui M, Theophanides T, Mamarelis I.

Abstract
There are many clinical evidences that hyperuricemia is a risk factor for the development of
peripheral carotid and coronary vascular diseases. However, the mechanism of elevated uric
acid concentration in biological systems is not yet clear. In the present work Fourier transform
infrared (FT-IR) spectroscopy was used to evaluate the mechanism of calcification and plaque
formation in carotid arteries in hyperuricaemic patients. Comparison between the spectra of
carotid arteries from patients with elevated uric acid values and spectra obtained from patients
with normal uric acid values showed structural changes of the characteristic spectral bands in
the region 4000-500 cm-1. These changes were related with changes in the concentration of
the serum uric acid and the clinical history of the patients. The intensity decrease of the infrared
bands in the region 1650-1500 cm-1 was associated with the decrease of the apolipoprotein
ratio, ApoI/ApoII, which corresponds to HDL (High Density Lipoproteins) and the regulation
of the LDL (Low Density Lipoproteins), which are related to oxidation stress. The infrared
band at 1467 cm-1 indicated the presence of urea components as a result of the metabolic
pathway. The shape and the intensity of the bands between 1250-900 cm-1 depend on the
glycation-end products of the diseases. SEM-EDX chemical analysis showed fibril formation
and molybdenum release in hyperuricaemic patients.

Key words: infrared spectroscopy, oxidative stress, molybdenum enzymes, hyperuricemia uric acid, SEM-EDEX



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