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Research Article

EJMCM. 2019; 6(1): 03--11

Zhengyuan capsule alleviates chemotherapy-related fatigue in nude mice with human lung adenocarcinoma A549 xenografts

Jieshan Guan, Lizhu Lin, Mingzi Ouyang.

Aim: We aimed to investigate the action mechanism of Zhengyuan capsule (a registered
proprietary Chinese medicine) against chemotherapy-related fatigue (CRF).
Methods: BALB/c-nu nude mice model with human lung adenocarcinoma A549 xenografts
was constructed by injection of A549 cell suspension. The xenografted mice were randomly
divided into model, cisplatin and cisplatin+Zhengyuan groups (n = 20 each). The cisplatin
group was given an intraperitoneal injection of 5 mg/kg cisplatin every 3 days for 21 days.
The cisplatin+Zhengyuan group was given an intragastric administration of cisplatin and 25
mg/kg Zhengyuan capsule each day for 21 days. Normal control and model groups were
administrated with equal amount of saline. Forced swimming assay, tail suspension test, open
field test, hepatic glycogen assay, blood analysis, and bone marrow smear was performed.
Results: The cisplatin group developed CRF after receiving chemotherapy. When compared
with cisplatin group, the cisplatin+Zhengyuan group exhibited longer exhaustive swimming
time (p

Key words: chemotherapy-related fatigue; lung cancer; Zhengyuan capsule; hepatic glycogen; bone marrow suppression; cytokine

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