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Review Article

EJMCM. 2020; 7(1): 05-09


Genetic and Cell biology Discriminants of Sars-CoV2 Infection and Susceptibility to Covid-19 pulmonary complication

P Scalia, SJ Williams, R Luca’, Antonio Giordano, E Bucci.

Abstract
The agent of Covid19, Sars-CoV-2 has caused
thousands of fatalities worldwide and overshadowed
the number of deaths of other previous coronavirus
outbreaks (Sars-CoV1 2002 and MERS-CoV 2012).
Although the new coronavirus pathogenicity is
actively under investigation, part of its infectious
behavior can be linked to its higher binding affinity
to the angiotensin-converting enzyme 2 (ACE2)
in the respiratory tracts. However, the expression
of ACE2 per se may not be sufficient to justify the
individual variability observed among affected
patients in terms of clinical outcome in apparently
non-immune depressed, non-elders subjects.
The present update provides an overview of the
most recent scientific findings related to genetic
factors involved in the Sars-CoV-2 infectious
process and their potential role in affecting the
virus pathogenicity. The present update can
provide valuable hints towards developing a
predictive screening/susceptibility profile testing
on individuals not yet infected and/or in nonsymptomatic
positive subjects towards managing
the current morbidity and mortality risk and
establishing personalized intervention protocols for
the early treatment of the Sars-CoV-2-associated
life-threatening pulmonary complication.

Key words: The morbidity and the mortality of Coronavirus infectious disease 19 (Covid19) (Zhou et al., 2020) is linked to lung failure observed in those subjects with pulmonary distress requiring intensive care treatment.


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