Since there is no specific treatment for COVID-19 yet, the only means to survive this disease is to consolidate the immune system. In addition, as the immune system is closely linked to the neuroendocrine system, any kind of psychological stresses that overwhelm this association causes immune dysfunction. In this context, self-confidence that can mitigate psychological stresses posed by COVID-19 can play an important role in consolidating immune response against this disease (Figure 1). An in-depth understanding of how psychological stresses overactivate the neuroendocrine-immune axis, weakening the immune system, and how self-confidence interferes with the overwhelmed immune response may offer a prospective strategy for the prevention as well as effective management of COVID-19.
Key words: Self-confidence, CNS, endocrine, immune responses, COVID-19
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