Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Article

Int Med. 2021; 3(1): 4-9


Interferon-lambda 3 is involved in the permission of pneumonia development after infection with respiratory viruses including SARS-CoV-2

Lyudmila Ivanovna Nikolaeva, Georgy Vitalievich Sapronov, Veronika Vasilievna Dyachenko, Nataliya Mikhailovna Glagoleva, Nadezhda Grigorievna Shevchenko, Ekaterina Gennadievna Samokhvalova, Evgeniya Andreevna Mkasheva, Alexandra Georgievna Rosatkevich, Irina Nikolaevna Khlopova, Lylya Nikolaevna Merkulova, Irina Sergeevna Kruzhkova, Alexander Evgenievich Grishechkin, Svetlana Vasilievna Smetanina, Lyudmila Vladimirovna Kolobukhina, Elena Ivanovna Burtseva, Dmitry Konstantinovich Lvov.

Abstract
Background: The effectiveness of barrier function of the respiratory mucosa largely depends on interferons type I (IFNs-α/) and type III (IFNs-λ). The IFNs-λ forms the first level of innate immune protection. The single-nucleotide polymorphisms (SNPs) affecting IFN-λ3 production were found previously. The study aimed to investigate a putative association of SNPs rs8099917 T/G located upstream IFNL3 gene and rs12979860 C/T within IFNL4 gene with a risk of pneumonia developing after infection with respiratory viruses.
Methods: The nasopharyngeal swabs, lavages, and blood samples from 318 patients infected with respiratory viruses were analyzed. Of these, 168 participants were shown to have community-acquired pneumonia, while the rest patients were diagnosed with bronchitis. The respiratory virus genomes were detected by real-time polymerase chain reaction (PCR) using commercially available kits. The DNA samples from all patients were used to detect SNPs rs8099917 T/G and rs12979860 C/T by real-time PCR using a commercially available kit. COVID-19 morbidity and mortality data were obtained from the WHO website.
Results: No association was found between different rs8099917 allelic variants and the development of pneumonia. The rs12979860 TT genotype was significantly more often detected in patients with pneumonia (p = 0.039; OR = 2.400; 95% CI 1.310 - 3.706). IFN-λ3 production has been early found to be maximal with rs12979860 TT genotype. An association was established between rs12979860 T allele frequency and COVID-19 mortality rate in 13 countries.
Conclusions: The rs12979860 TT genotype is a genetic marker of increased risk of pneumonia after infection with respiratory viruses. High T allele frequency may be an indicator of a higher COVID-19 mortality rate. Patients with rs12979860 TT genotype have an increased risk of developing COVID-19 pneumonia.

Key words: COVID-19; genetic polymorphisms; IFN-λ; pneumonia; respiratory virus infection



Similar Articles

Growth differentiation factor 5: a neurotrophic factor with neuroprotective potential in Parkinson's disease.
Goulding SR, Anantha J, Collins LM, Sullivan AM, O'Keeffe GW
Neural regeneration research. 2022; 17(1): 38-44

Dissecting lipid droplet biology with coherent Raman scattering microscopy.
Chen T, Yavuz A, Wang MC
Journal of cell science. 2022; 135(5):

Cell cycle exit and neuronal differentiation 1-engineered embryonic neural stem cells enhance neuronal differentiation and neurobehavioral recovery after experimental traumatic brain injury.
Wang R, Yang DX, Liu YL, Ding J, Guo Y, Ding WH, Tian HL, Yuan F
Neural regeneration research. 2022; 17(1): 130-136

Hypoxia inducible factor and diffuse white matter injury in the premature brain: perspectives from genetic studies in mice.
Guo F, Zhang S
Neural regeneration research. 2022; 17(1): 105-107

Small scale adeno-associated virus-vector production for preclinical gene delivery based on chloroform precipitation.
Davidsson M, Heuer A
Neural regeneration research. 2022; 17(1): 99-100


Full-text options


Add your Article(s) to Indexes
• CiteIndex: Articles & Statistics







Advertisement
American Journal of Diagnostic Imaging

SUBMIT YOUR ARTICLE NOW




ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.