Lead is the most abundant toxic metal in the environment that causes serious health hazards in animals and humans. In this study, prophylactic effects of vitamin E and coriander (Coriandrum sativum L.) seed extract on lead-induced liver damage in Swiss albino mice were investigated by gross and histological studies. At first, mice were intoxicated with particular dose of lead acetate for 42 days. After intoxication, mice were divided into three groups for treatment purpose. First and second group of mice were treated with vitamin E and coriander extract respectively. Both vitamin E and coriander extract were given to the third group of mice. Treatment was done for 42 days. In this study, lead acetate was found to cause nodular lesion and congestion in central vein in liver. Vitamin E was found effective in the treatment of congestion in central vein of liver but ineffective in the treatment of nodular lesion. Nodular lesion was found in liver even after treatment of vitamin E. Liver was found normal in coriander extract treated group as well as vitamin E and coriander extract combined treated group. There was no nodular lesion as well as congestion in central vein of liver in these two groups. The present findings revealed that lead has detrimental effects on liver of mice. Treatment with coriander extract was found more effective than the treatment with vitamin E in lead intoxicated mice. Combined action of vitamin E and coriander extract is more effective than their individual action. The present investigation may serve as baseline data about adverse effects of lead toxicity and efficacy of vitamin E and coriander extract against lead toxicity.
Key words: Lead, hepatotoxicity, vitamin E, coriander, mice.
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