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Research Article



Biochemical and Safety Examination of Ethanol Extract of Justicia Carnae on PHZ -Produced Anaemia in Wistar Rats

Ikpeazu O.V., Igwe K.K., Otuokere I.E..



Abstract
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The leaves of Justicia carnae were screened for a hematological and biochemical response using serum enzyme activities in rats. Twenty-five rats were used in this research and were grouped into 5 of 5 rats each. Group 1 was a negative control group and was treated with distilled water. Groups 2 entreated anaemic, 3, 4 and 5 were treatment groups and received 100, 200 and 400 mg/kg body weight of the J. carnae extract, respectively. Anaemic was induced with Phenylhydrazine (PHZ). The rats were treated for 14 days, thereafter was sacrificed and blood collected from the heart for analysis. The effect of J. carnae extract was checked on hematological parameters and serum enzyme activities. All results in treatment groups were compared with the untreated anaemic group 2 at statistical confidence p

Key words: Anaemia, Blood cells, Marker-Enzymes, Justicia carnae , Phenylhydrazine, Safety







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