Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Research

Assessment of BCL-2 expression in actinic keratosis, keratoacanthoma and seborrheic keratosis cases

Sevda Onder, Havva Erdem, Nurten Turhan Haktanir, Hilal Balta, Muruvvet Akcay Celik.

Aim: One of the main functions of apoptosis is the elimination of cells with damaged DNA, including premalignant cells in skin.
Apoptosis is regulated by the balance between antiapoptotic and proapoptotic proteins. The bcl–2 protein has been shown
antiapoptotic effect. It protects cell against apoptosis induced by different death-inducing signals.
Material and Methods: In this study the authors have analyzed imunohistochemically the expression of bcl-2 protein in the
histopathological variants of the precancerous lesion [actinic keratosis (AK) (28 cases) and keratoacanthomas (KA) (12 cases) and
seborrheic keratosis (SK) (22 cases) in skin.
Results: In cases of AK, bcl-2 expression was confined to basal cell layer, as well as in two cases of thorough epidermis. SK expression
of bcl–2 protein was in areas of basaloid proliferation.KA expression of bcl-2 protein was not dome-shaped keratin-filled crater
areas but bcl-2 expression was confined of non crater areas.
Conclusion: In conclusion, bcl-2 expression supports the observation that tumor cells are derived from basal keratinocytes in AK and
SK and not support the observation that tumor cells are derived from basal keratinocytes in KA.

Key words: bcl-2; Actinic Keratosis; Keratoacanthoma; Seborrheic Keratosis.

Full-text options

Full-text Article

Journal of Contemporary Medical Education


BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.