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Research Article

JCR. 2020; 7(10): 412-415


THE EFFECTIVENESS OF TRIMETAZIDINE AND ITS COMBINATION WITH METHYLDOPA IN EXPERIMENTAL PREECLAMPSIA

Oksana E. Antsiferova, Vladimir V. Gureev, Anastasia V. Gureeva, Marija A. Zatolokina, Il'ya S. Rozhkov, Adelaida V. Polyanskaya.

Abstract
Introduction
Objective of the study: To investigate the effectiveness of trimetazidine and its combination with methyldopa with preeclampsia in an experiment.
Methods: The experiment was performed in 140 white female Wistar rats weighing 250-300 g. L-NAME was administered intraperitoneally (25 mg / kg / day) from 14 to 20 days of gestation. Trimetazidine (6 mg / kg) was administered intragastrically 1 time per day from 14 to 20 days of pregnancy. Methyldopa (2x0.043 g / kg) was administered 2 times a day from 14 to 20 days of pregnancy. On 21 days of pregnancy, functional tests and laboratory tests were performed.
Results: The admistration in animals of trimetazidine leads to a pronounced correction of pathological changes in experimental ADMA-like preeclampsia. The greatest effect was observed with combined methyldopa. A significant decrease in systolic and diastolic pressure was noted, respectively, improved microcirculation in the placenta, restoration of the NO-synthesizing endothelial function, and a decrease in proteinuria.
Conclusion: The results of the study indicate the promise of using trimetazidine for the correction of morphological and functional changes in preeclampsia and substantiate the feasibility of further studies in this direction.

Key words: Trimetazidine, Preeclapsia, Endothelial Dysfunction, Rats, Proteinuria, Microcirculation.



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