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Research Article

JCR. 2020; 7(14): 1137-1143


MICROEMULGEL: A PROMISING APPROACH TO IMPROVE THE THERAPEUTIC EFFICACY OF DRUG.

Ganesh R. Pawbake, Satish V. Shirolkar.

Abstract
Emulgel is such a unique feature of a topical drug delivery system that localizes and directly accepts the drug through ophthalmic, skin & rectal pathways throughout the body. The use of gel has expanded in cosmetics and pharmaceutical preparations between the different groups of semisolid preparations. Despite gel, the delivery of hydrophobic medicinal products is restricted. This can be overcome by using a new system of drug delivery, i.e. MICRO emulgel. Microemulgel has the advantage of double emulsion and gel benefits with a variety of other desirable properties such as a right consistency, thyrotropic, grazing, easily spreadable as well as removable, emollient, water-soluble, long shelf life, organic, transparent, pleasant look, self-medication ability of patients, termination of medications. The high solubility of an API and oil can also have more or less pharmacological properties, and can, therefore, support the therapeutic action of the API. Due to the presence of the oil portion, the API penetrates the skin further. The Oil Micelle size was less than 500 nm which allows more penetration and higher efficiency than macroemulsion in the skin for API absorption. This review is highlighting on the different aspect of microemulgel to improve the therapeutic window of drug.

Key words: Micro emulgel, Topical drug delivery, hydrophobic drugs.



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