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Review Article

SRP. 2020; 11(6): 213-220


Methodical Basis for Analysis of Monosaccharide Profile of the Polysaccharide Complex in the Mixture Herbal Product (Pectorales Species No 2)

Chevidaev V.V., Bokov D.O., Potanina O.G., Nikulin A.V., Nasser R.A., Samylina I.A., Sokhin D.M., Sergunova E.V., Bobkova N.V., Kovaleva T.Yu., Rendyuk T.D., Janulis V., Morokhina S.L., Grikh V.V., Krasnyuk I.I. (junior), Galiakhmetova E.K., Moiseev D.V..

Abstract
Background: Mucolytic and expectorant drugs are important elements in the pharmacotherapy of respiratory diseases. Phytopectol No 2 (Pectorales species No 2) is one of the herbal multi-component drugs (herbal teas). Pectorales species No 2 (PS No 2) is a mixture of three types of medicinal plants presented on the Russian pharmaceutical market. It consists of coltsfoot leaves (40%), plantain leaves (30%), and licorice roots (30%). The PS No 2 infusion is a dosage form prepared from crushed or powdered plant material. The PS No 2 infusion exhibits expectorant and anti-inflammatory activity; it is used in the treatment of respiratory diseases and to facilitate the release of sputum.
Purpose: This review study aims to collect and analyze the literature data concerning the composition and content of polysaccharides, their monosaccharide composition in PS No 2 and its components.
Methods: We used different scientific databases such as PubMed, Scopus, Web of Science, e-Library, Google Scholar for information search.
Result: Nowadays, synthetic drugs, herbal remedies, and combined medicines with expectorant action are presented on the Russian and world markets. Herbal medicines can be classified into single drugs containing one plant/component, and medicines with two or more plants/components. Herbal medicines take leading places in the segment of the mucoactive drugs market along with synthetic ones in the Russian Federation. Most of the PS No 2 polysaccharides are arabinogalactans, rhamnogalacturonans, galacturonans, galactans. The arabinose (up to 15%), glucose (up to 26%), galactose (up to 23%), rhamnose (up to 40%), as well as galacturonic acid (up to 26%) are presented in monosaccharide composition of PS No 2 polysaccharide complex.
Conclusion: Polysaccharides of various types are the main group of biologically active compounds (BAC) in PS No 2. The monomer composition of the polysaccharides causing the pharmacological action of PS No 2 should be established to improve the standardization procedures of crude herbal drugs and to identify BAC. The ratio of these carbohydrates can serve as a marker parameter in the standardization of PS No 2.

Key words: coltsfoot leaves, plantain leaves, licorice roots, Pectorales species No 2, polysaccharides, monosaccharides


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