The emergence of multidrug resistance among pathogens has become a global challenge for bacterial infection
treatment. The methicillin-resistant Staphylococcus aureus, multi-drug resistant tuberculosis and antibacterial resistant E. coli
is the leading cause of mortality among infectious diseases worldwide. Finding a novel chemical to combat antibiotic resistance
microorganisms is critical right now in the world. In this study we synthesized five novel primaquine derivatives and evaluated
their efficacy against methicillin-resistant Staphylococcus aureus, multi-drug resistant tuberculosis and antibacterial resistant
E. coli. All the molecules show excellent antibacterial activity against antimicrobial resistance microorganisms compared to
standard drugs.
Key words: Primaquine, Synthesis, Antimicrobial resistance, MRSA, E. coli, MDR-TB
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