This study was conducted to identify the genetic polymorphisms of the cytotoxic T-lymphocyte-associated protein 4 (CTLA4) gene and protein tyrosine phosphatase non-receptor 22 (PTPN22) gene to investigate the possible association of their polymorphism with the development or progression of hyperthyroidism. Two genetic loci covering two regions within the CTLA4 and PTPN22 genes were amplified by PCR. Next, a direct sequencing strategy was performed for the observed PCR amplicons to assess the pattern of genetic polymorphism in the screened specimens. Subsequently, the observed variants were localized according to their positions within the referring genomic DNA sequences. The results indicated a significant increase (P
Hyperthyroidism , CTLA-4 , polymorphism, PTPN22, SNP
MicroRNAs in Genetic Etiology of Human Diseases.
Olcum M, Tufekci KU, Genc S
Methods in molecular biology (Clifton, N.J.). 2022; 2257(): 255-268
Genome features of common vetch () in natural habitats.
Shirasawa K, Kosugi S, Sasaki K, Ghelfi A, Okazaki K, Toyoda A, Hirakawa H, Isobe S
Plant direct. 2021; 5(10): e352
Construction of a high density genetic map for hexaploid kiwifruit (Actinidia chinensis var. deliciosa) using genotyping by sequencing.
Popowski E, Thomson SJ, KnÃ¤bel M, Tahir J, Crowhurst RN, Davy M, Foster TM, Schaffer RJ, Tustin DS, Allan AC, McCallum J, ChagnÃ© D
G3 (Bethesda, Md.). 2021; ():
Associations of TP53 codon 72 polymorphism with complications and comorbidities in patients with type 1 diabetes.
SÅ‚omiÅ„ski B, Skrzypkowska M, Ryba-StanisÅ‚awowska M, MyÅ›liwiec M, Trzonkowski P
Journal of molecular medicine (Berlin, Germany). 2021; 99(5): 675-683
Association of VEGF haplotypes with breast cancer risk in North-West Indians.
Sambyal V, Guleria K, Kapahi R, Manjari M, Sudan M, Uppal MS, Singh NR
BMC medical genomics. 2021; 14(1): 209