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Review Article

SRP. 2020; 11(6): 159-168

Detection of CTLA- 4 and PTPN22 Genes Polymorphisms and Relationship with Hyperthyroidism Patients in Thi-Qar Province¬, Iraq.

Rasha Salih Nuhair, Nabeel Mahdi Abid, Shaymaa Z.Al-Rumaidh.

This study was conducted to identify the genetic polymorphisms of the cytotoxic T-lymphocyte-associated protein 4 (CTLA4) gene and protein tyrosine phosphatase non-receptor 22 (PTPN22) gene to investigate the possible association of their polymorphism with the development or progression of hyperthyroidism. Two genetic loci covering two regions within the CTLA4 and PTPN22 genes were amplified by PCR. Next, a direct sequencing strategy was performed for the observed PCR amplicons to assess the pattern of genetic polymorphism in the screened specimens. Subsequently, the observed variants were localized according to their positions within the referring genomic DNA sequences. The results indicated a significant increase (P

Key words: Hyperthyroidism , CTLA-4 , polymorphism, PTPN22, SNP

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