Abstract

Fibrates, wide-spectrum fibric acid derivatives, are used for dislipidemia and hypertriglyceridemia treatment. The adverse effects are on striated muscles, kidney, and liver but the most serious and potentially mortal effect is rhabdomyolysis. Rhabdomyolysis is a clinical and biochemical syndrome resulted from acute necrosis of striated muscles and release of these into the circulation due to traumatic (earthquake, road accident etc.) or non-traumatic causes. Clinical course may vary from an asymptomatic syndrome to myopathy, life-threatening hypovolemic shock, cardiac arrhythmias or acute renal failure. Myoglobinuria is the most prominent consequence of muscle cell damage that results with renal failure in 15-33% of patients. In this paper, a case with myopathy and rhabdomyolysis, as a result of fenofibrate treatment is presented.

Key words: Fibrates, rhabdomyolysis, myopathy