Abstract

In our study we have a tendency to synthesized schiff’ base of bactericide drug sulphanilamide on treating with
aromatic aldehydes like p-diethyl amino benzyldehyde and p-dimethyl amino benzyldehyde. The synthesized schiff’s bases
were regenerate to its ion Schiff bases by treating with methyl group halide. The ion Schiff bases were regenerate to metal
complexes by treating with metals like CuCl2, ZnCl2 and CdCl2. All the synthesized compounds were characterised by
Elemental analysis, IR and 1H proton magnetic resonance. Docking study was performed to know the interaction of binding
sites with protein receptor using MAO-B enzymes (PDB ID: 2BK5) and COX-2 enzyme (PDB ID: 5IKR) by Virtual
Screening software for Computational Drug Discovery. Synthesized metal complexes were evaluated for antibacterial, anti
inflammatory and antidepressant activity. Copper metal complexes showed potent antibacterial and anti-inflammatory
activity. Significant anti-depressant activity was shown for 1A2 and 1B2 zinc metal complexes.

Key words: Sulphanilamide, antibacterial, anti-inflammatory, antidepressant activity