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Review Article

SRP. 2020; 11(6): 31-35

Morphofunctional Aspects of Bone Tissue at Osteoporosis

Vladimir F. Kulikovsky, Tatyana V. Pavlova, Ilya P. Bashuk, Natalia B. Pilkevich, Lubov A. Pavlova.


Objective: morphofunctional aspects of bone tissue at osteoporo-sis.
Methods: The clinical material of 117 patients with isolated and multiple fractures of typical localizations on background of systemic osteoporosis as well with degenerative diseases of the musculoskele-tal system, which were presented by deforming arthrosis of hip joints of 3rd degree. The specimens of bone tissue were browsed and pho-tographed in light microscope «TOPIC-T» CETI. The specimens were fixed in standard glutaraldehyde fixative and then they were browsed in raster electron microscope «FE1 Quanta 200 3D» и «FE1 Quanta 600 FEG»( Netherlands). The processing and formation of AFM- images were conducted using software «NOVA»(NT-MDT, Russia) and «Image Analysis» (NT-MDT, Russia).
Results: The decreasing of total area of bone tissue was morpholog-ical manifestation of osteoporosis. Normal bone plates in cancellous bone became thin and perforated, trabecular lattice system also be-came thinner and partially interrupted. Trabeculae became thin, distance between them increased, what led to spreading of bone marrow space. The structure of Havers canals was violated. The thinning of tissue in cancellous substance was due to transformation of endoste-al layer of cortical bone. The fibres of intercellular substance of bone tissue were placed randomly, large intervals were between bunches.
Conclusions: At exploration of morphofunctional features of bone tissue at osteoporosis it was founded that the decreasing of total area of solid substance in bone tissue took place. In cancellous substance bone plates became perforated and thin, collapsed, forming large cavities. Trabecular lattice system became thin and partially interrupt-ed. Trabeculae became thin, distance between them increased.

Key words: osteoporosis, bone tissue, bone fracture, old age

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