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Technical Note

SRP. 2020; 11(6): 16-20


Polymorphism of CYP2C9 Gene in Patients with Stable Angina Pectoris and its Significance in Pathogenesis of the Disease

Olesya V. Romaschenko, Eduard A. Snegin, Nina I. Zhernakova, Petr K. Alferov, Lyudmila R. Zakirova, Vadim V. Rumbesht, Natalia D. Grischenko, Olga A. Osipova.


Abstract

Introduction: This study was carried out in the direction of personalized medicine, based on identifying the genetic characteristics of patients, which can affect the pathogenesis of the disease and the effectiveness of pharmacotherapy.
Research tasks: To study of the polymorphism of the cytochrome CYP2C9*2 C430T gene in patients with stable angina pectoris and to evaluate the significance of this factor in pathogenesis of the disease.
Material and Methods: A study of 90 patients with stable angina pectoris was performed. The polymerase chain reaction was used to determine the gene polymorphisms of cytochrome CYP2C9*2 C430T. The condition of DNA was studied by the method of DNA comet assay.
Results and Discussion: The presence of gene polymorphisms by the alleles CYP2C9*2 C430T was found. They revealed a more severe clinical condition of patients with pathological genes by the alleles CYP2C9*2 C430T (CT genotype) in comparison with patients with normal genotype for this allele (CC): a higher functional class of angina pectoris, overweight, blood hypercoagulability, an increased level of personal anxiety and greater DNA damage.
Conclusion: polymorphism of the cytochrome CYP2C9*2 C430T gene is essential in the pathogenesis of angina pectoris: in patients with the pathological genotype of cytochrome CYP2C9*2 C430T gene there were revealed more severe clinical condition.

Key words: polymorphism of the gene CYP2C9*2 C430T, stable angina pectoris, pathogenesis, personalized pharmacotherapy.






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