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SRP. 2020; 11(5): 464-468

Comparative Study of the Efficacy of Flunixin, Ketoprofen and Phenylbutazone in Delman Horses with Mild Colic

Agus Purnomo, Arya Pradana Wicaksono, Dodit Hendrawan, Muhammad Thohawi Elziyad Purnama.


This study aimed to evaluate the efficacy of flunixin, ketoprofen and phenylbutazone on serum biochemistry, plasma catecholamines and serum cortisol in Delman horses with mild colic. During the study period, 32 horses were evaluated due to mild colic. Flunixin, ketoprofen, and phenylbutazone were administered intravenously at the recommended dose rates of 1.0; 2.2 and 4.4 mg/kg, respectively. Administration of the NSAIDs commenced on Day 1 and continued every 12 h for 12 days. Blood samples collected between days 2, 5, 9 and 13 to evaluate AST, ALP, GGT, creatinine, urea, epinephrine, norepinephrine, and cortisol level. The data analysis performed using Multivariate analysis of variance (Manova) followed by Duncan multiple range test. The results showed a significant alleviation in all observed variables on Day 13, although the use of various NSAIDs showed no significant difference.

Key words: serum biochemical, catecholamine, cortisol, colic, NSAIDs

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