Pain is one of the health problems that really common in the field of medicine. Complaints of pain themselves are subjective and can affect the quality of life of patients. Therefore, a good understanding is needed to be able to diagnose and treat pain comprehensively. Along with the changing lifestyle in the community, the prevalence of diabetes mellitus (DM) also increased. Diabetic peripheral nerve (DPN) is a complication that often occurs in people with DM. This complication is the biggest cause of morbidity and mortality in patients with DM. There are several pathways that are thought to have a significant effect on the incidence of diabetic neuropathy, such as the activation of the polyol pathway from the hexosamine pathway and protein kinase C (PKC), the accumulation of advanced glycation end products (AGEs) in diabetic nerves, excessive levels of glucose and fatty acids. The last few decades of research suggest that there are transcription factors that affect the incidence of diabetic neuropathy will be discussed in this article.
Key words: Diabetic Peripheral Nerve, Neuropathic Pain, Diabetes Mellitus