Home|Journals|Articles by Year

Directory for Medical Articles
 

Review Article

SRP. 2020; 11(5): 421-430


Evaluation the Predictors of Non-Alcoholic Fatty Liver Disease (NAFLD) in Type 2 Diabetes Mellitus (T2DM) Patients

Amer Alasadi, Haider Hafudh Humaish, Husam Al-hraishawi.


Abstract

Background: NAFLD is the chronic form of liver fatty disease, which is vastly common over all worldwide. It is highly connected with T2DM that is defined by hyperglycemia, insulin resistance (IR), and hepatic malfunctions. Our study was design to determine the predictors for NAFLD’ incidence in T2DM patients.
Methods: We conducted study of 299 subjects that were classified into two groups, (110) Non-Diabetic subjects and (189) T2DM patients, then the T2DM patients divided into two groups: T2DM (99) and DM+pre-NAFLD (90) patients. We measured hyperglycemia tests, Total Cholesterol, Triglycerides (Tg), Low-Density Lipoprotein Cholesterol (LDL-C), High Density Lipoprotein Cholesterol (HDL-C), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), AST/ALT ratio, and γ-Glulamyltransferase for all groups. We determined the Triglyceride Glucose index, Interleukin-6, Alkaline Phosphate (ALKP), and C Reactive Protein (CRP) levels as biomarkers for IR and NAFLD respectively.
Results: Our data demonstrated that DM+pre-NAFLD patients exhibited a significant increased in TC, TG, and LDL-C, and dramatic decreased in HDL-C compared to DM patients and Non-DM subjects. -AST, ALT, AST/ALT ratio and GGT levels showed a significant elevation in DM+pre-NAFLD and DM patients compared to the Non DM subjects. The data showed that TyG Index, IL-6, CRP and ALPK levels were increased in DM+pre-NAFLD patients only. The data showed a positive correlation between dyslipidemia, and liver function tests with IR and NAFLD biomarkers in DM+pre-NAFLD patients only.
Conclusions: In T2DM, dyslipidemia deters liver enzymes functions, promotes the IR and increases the fatty liver accumulation. Liver enzymes, TyG Index, IL-6, CRP and ALPK could be non-invasive biomarkers for NAFLD in T2DM patients.

Key words: Predictors, non-alcoholic fatty liver disease, 2 Diabetes Mellitus.






Full-text options


Share this Article



Online Article Submission
• ejmanager.com
• ojshosting.net







Do you want to use OJS for your journal ?
work with an experienced partner
www.OJSHosting.net

eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.