Background:Obstetric hemorrhage remains one of the major determinants of maternal
death in both developed and developing countries. Because of its weight as a leading cause
of maternal mortality and morbidity, obstetric hemorrhage (ante-partum and post- partum
hemorrhages) must be investigated for national guideline development.The present study
was planned todetermine the efficacy of tranexamic acid (TXA) in reducing blood loss
during and after caesarean section (CS), as well as its safety.Methods:The current study was
randomized controlled clinical trial conducted at Department of Obstetrics and Gynecology
in Zagazig University Hospitals, from April 2021 to September 2022. Included 78 women
ages were from 18 - 48 years old and gestational age from 35 - 42 weeks with risk factor for
Postpartum hemorrhage (PPH). All patients were assessed by full history with particular
attention to bleeding tendency.Results: There is statistically significant lower value of HB,
HCT post cesarean delivery of high-risk pregnancy compared to its value pre CS among
control group p
Key words: Tranexamic acid , Postpartum haemorrhage , caesarean section
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