Nanotechnology has gained non- replaceable role in a host of applications in biomedical, agricultural, consumer, military and in industrial sectors. However, when observed through the perspective of central nervous system particularly, studies evidently provide data on both beneficial and detrimental effects of nanoparticles. While there exist a milieu of beneficial applications like axonal regeneration, Central Nervous System (CNS) imaging, neurological surgeries etc., nanoparticles open the doorway for an array of toxic reactions in CNS centers because of their effortless passage through brain barriers.Even though literatures endow with generalized toxic mechanisms mediated by nanoparticles in varying tissues, specific toxic reactions in CNS are still lacking. Present review mainly focuses on different routes through which nanoparticles get access into the brain and certain modes of toxic mechanisms exhibited by nanoparticles in CNS. A number of applications of nanoparticles in the diagnosis and treatment of CNS disorders also will be reviewed in concise.
nanoparticles, blood brain barrier, nanotoxicity, cellular response, oxidative stress