The purpose of this study was to investigate whether biochemical parameters on admission can predict the development of acute stent thrombosis within 24 hours of presentation in patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). This retrospective study included patients who were hospitalized for acute STEMI and treated with primary PCI between September 2009 and May 2018. The patients were divided in to two groups according to the presence or absence of acute stent thrombosis following primary PCI. After comparison of biochemical parameters in the two groups, variables displaying difference between the two groups were further analyzed for their predictive role in stent thrombosis. Two hundred and twenty-two STEMI patients treated with primary PCI were enrolled in the study. Among these, 102 experienced acute stent thrombosis within 24 hours of presentation. There was no significant difference instant diameter, stent length and ejection fraction between the groups. Age ,gender, diabetes, hypertension and smoking status were comparable between the two groups. Serum bilirubin and uric acid levels were significantly higher in the stent thrombosis group than the non-stent thrombosis group. Logistic regression analysis revealed that uric acid (OR: 1.482, 95% CI: 1.23-2.342, p=0.034) and total bilirubin (OR: 1.733 95% CI: 1,12-2.046, p= 0.003) levels were significant predictors for stent thrombosis in subjects admitted with STEMI. Admission serum bilirubin and uric acid levels may predict acute stent thrombosis in STEMI patients undergoing primary PCI.
Key words: Stent, thrombosis, bilirubin, uric acid, myocardial infarction