Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Research



Prophylactic Effect of Cyperus Esculentus Milk on High Dose Acetaminophen Model of Hepatic Toxicity in Wistar Rats

Dorcas Akinloye, Oluseyi Akinloye, Adeola Adejumo.

Abstract
Cyperuses esculentus is a wholesome nut with notable nutritional and medicinal benefits. This study investigated the prophylactic impact of Cyperus esculentus milk extract (CE) on high dose acetaminophen-induced liver impairment in experimental rats. Thirty rats of weight between 155-220 grams were randomly distributed into 5 groups (n=5). Groups 1 and 2 were without treatment, while rats in groups 3, 4, 5 and 6 were orally administered 8.57mg ascorbic acid, 100 mg/kg, 200mg/kg and 400mg/kg of body weight CE respectively for 21 days. On the 22nd day of the experiment, 1g/kg body weight of acetaminophen was administered orally to rats in group 2 to 5. The serum and liver was collected for analyses. Histopathology of the liver was delved into. CE and the standard drug (ascorbic acid) at selected doses appreciably decreased serum activities (p

Key words: Acetaminophen, Cyperus esculentus, biomarkers, hepatoprotective.



Full-text options

Full-text Article




Advertisement
American Journal of Research in Medical Sciences

SUBMIT YOUR ARTICLE NOW




ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.