Cyperuses esculentus is a wholesome nut with notable nutritional and medicinal benefits. This study investigated the prophylactic impact of Cyperus esculentus milk extract (CE) on high dose acetaminophen-induced liver impairment in experimental rats. Thirty rats of weight between 155-220 grams were randomly distributed into 5 groups (n=5). Groups 1 and 2 were without treatment, while rats in groups 3, 4, 5 and 6 were orally administered 8.57mg ascorbic acid, 100 mg/kg, 200mg/kg and 400mg/kg of body weight CE respectively for 21 days. On the 22nd day of the experiment, 1g/kg body weight of acetaminophen was administered orally to rats in group 2 to 5. The serum and liver was collected for analyses. Histopathology of the liver was delved into. CE and the standard drug (ascorbic acid) at selected doses appreciably decreased serum activities (p
Acetaminophen, Cyperus esculentus, biomarkers, hepatoprotective.