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Original Research

ECB. 2022; 11(9): 54-59

Formulation and Evaluation of Liquid Self Nano-Emulsifying Drug Delivery System of Lovastatin

Nurhabibah Nurhabibah, Akhmad Kharis Nugroho, Ronny Martien, Endang Lukitaningsih.


This study aimed to investigate the formulation and characterization of Lovastatin in an L-SNEDDS. The selected is composed of L-SNEDDS based on a solubility study of lovastatin in many oils, surfactants, and co-surfactants. Ternary phase diagrams were constructed based on lovastatin solubility to determine lower limit and high limit of oil, surfactant, and co-surfactant selected further to optimize the system using a D-Optimal mixture design. The optimized S of lovastatin was evaluated, including size particle, polydisperse index, and emulsification time. The optimal formula of L-SNEDDS was verified and determined size particle, polydisperse index, emulsification time, drug content, and dissolution of lovastatin. The results showed that the best formula is the composition of oleic acid 5,2%; tween 80 79,5%, and PEG 400 15,8%. The particle size is below 100 nm, the polydisperse index is below 0,5, and the emulsification time is below 20 seconds. The loading of SNEDDS lovastatin is 97,01%, and the SNEDDS of lovastatin composed of oleic acid, tween 80, and PEG 400 showed increasing dissolution of lovastatin than pure lovastatin
Keywords: L-SNEDDS, lovastatin, solubility, evaluation, dissolution

Key words: Keywords: L-SNEDDS, lovastatin, solubility, evaluation, dissolution

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