Introduction: Metformin in a therapeutic dose rarely causes hypoglycemia in type-I or type-II diabetes mellitus (DM-I, DM-II) patients. Previously, hypoglycemia due to metformin was attributed to other interfering factors.
Case report: A diabetic and hypertensive 50 years old man was diagnosed with one sever episode of hypoglycemia (38 mg/dl) and a second milder episode (57 mg/dl) associated with therapeutic doses of metformin.
Conclusion: Based on the literature data and the follow up of the case, the metformin-induced hypoglycemia might be due to an uncommon low-calorie diet and to a drug interaction with amlodipine anti-hypertensive medication. In such cases, a systematic evaluation is recommended to identify rare cases and to avoid tragic consequences.
Key words: hypoglycemia, metformin, amlodipine
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