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Research Article

JIRLS. 2019; 1(1): 89-96


ANTI-INFLAMMATORY ACTIVITY OF HYDROMETHANOLIC LEAF EXTRACT OF GREWIA CRENATA

Ukwuani-Kwaja AN and Abdulhamid A..

Abstract
Grewia crenata is a plant with acclaimed analgesic and anti-inflammatory properties amongst traditional bone setters in north- west, Nigeria. Hydromethanolic extract of Grewia crenata leaf (GCL) was assessed for its anti-inflammatory activity. Invitro anti-inflammatory activity was evaluated using membrane stabilization tests (heat and hypotonicity–induced hemolysis) and protein denaturation assay while the in vivo anti-inflammatory activity was accessed using eggalbumin- induced oedema model in albino rats.The results showed that GCL at a concentration range of 50 – 400 μg/ml significantly (p0.05) compared to Diclofenac sodium. However, the effect of the extract on hypotonicity-induced hemolysis was significantly increased (p

Key words: Anti-inflammatory activity, Grewia crenata, HRBC membrane, Hemolysis,Oedema



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