Home|Journals|Articles by Year|Audio Abstracts RSS - TOC
 

Original Article



Chromatographic profiling and anthelmintic activity of solvent fractions of aerial parts of Centratherum punctatum Cass. against Eisenia fetida

Maggalí González, Alberto Burgos-Edwards, Andrea Cáceres, Nelson Alvarenga.




Abstract
Cited by 1 Articles

In this work, the chromatographic profile of the methanolic extract of Centratherum punctatum Cass. was determined by LC-MS. Also, the anthelmintic activity of the extract and its fractions was assayed against Eisenia fetida. Ultrasound-assisted maceration with methanol as solvent was used to obtain the crude extract. The extract was submitted to liquid–liquid partition with solvents (hexane, chloroform, ethyl acetate, and water) for the obtention of the fractions. The crude extract and the fractions were assayed for anthelmintic activity using E. fetida as a model, being albendazole the positive control. Hydroxycinnamic acid derivatives, flavonoids, and sesquiterpene lactones were identified by LC-MS. The methanolic extract and the fractions showed a significant decrease in the times of paralysis and death compared to albendazole. These results suggest that the methanolic extract of C. punctatum and its fractions contain substances with potential anthelmintic activity. The plant could be a source of molecules useful for the development of new anthelmintic drugs.

Key words: Anthelmintic, Centratherum punctatum, LC-MS, Eisenia fetida






Full-text options


Share this Article



Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Review(er)s Central
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.