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Review Article

IJMDC. 2019; 3(2): 214-218

The role of Platelet-rich fibrin (PRF) in Periodontology

Shahad Mohammed Halawani, Burhan Nezar Hamdi, Maram Abdullah Al-Henaky, Zaid Yosef Almotawa, Sahar Amer Al-Harbi.


Periodontal disease is characterized by the loss of attached connective tissue and other periodontal tissues. Growth factors secreted from platelets promote tissue formation and wound healing. Platelet-rich fibrin (PRF) is composed of fibrin, platelets leukocytes and other cells that have a great role in different wounds healing processes. The aim of the current review was to highlight the role and mechanism of PRF usage in periodontal regeneration for periodontally affected teeth. A systematic search was made using an online database Medline to locate relevant peer-reviewed articles and textbooks published between 1990 to 2017 in English. Specific search keywords were used to obtain all possible articles concerned with the subject. We found 25 articles meeting our criteria and 20 of them were specifically related to the subject were selected for final analysis. Few studies have focused on the role of PRF in periodontology especially for periodontal regeneration and most of them were trials. PRF is considered a simple and inexpensive way for successful periodontal regeneration.

Key words: Periodontal regeneration, platelet concentrate, platelet-rich fibrin.

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