Humankind has used animals for food, transport and as a companion for many years now. The use
of animals in experimental research goes hand in hand with the creation of medicine which began in ancient
Greece. Experiments on animals could be carried out without great moral issues with the Cartesian method in the
17th century. The invention of anesthetics and the Darwin publication on the origin of species, which advocated
the biological resemblance of humans and animals, helped to increase the animal experiments. Animal
experiments were always considered essential as well as applicable to scientific research. This action must also
be explained from a moral standpoint, in addition to the scientific suitability requirements. This problem derives
from our civilizations’ requirement that animals be given a certain moral value. As guidelines for the performance
of animal experiments and the safety of lab animals, Burch's three Rs of “Replacement, Reduction, and
Refinement” is a field that can be described as a multidisciplinary branch of sciences. The greater interest and
concern about issues of animal welfare contributed to legislation in many countries and the setting up of
commissions on animal ethics. This paper includes an in-depth discussion on how to treat and use animals for the
biomedical research when conducting research.
Animal Rights, Biomedical Research, Cartesian method, Darwin publication, Ethics, Humankind,
Burch's three Rs.
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