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Original Article

J App Pharm Sci. 2022; 12(2): 165-171

Morphological and immunohistochemical effect of cerium dioxide nanoparticles on reparative osteogenesis of the jaw bones

Ernest Bazikyan, Andrey Chunikhin, Grigory Volozhin, Knarik Abraamyan, Vladimir Ivanov, Mariya S. Zudina.


Several modern scientific studies show that nanodispersed cerium dioxide (nanoCeO2 ) provides improved cell proliferation, including osteoblasts, antibacterial, and antiviral effects. In this study, using a comparative morphological, morphometric, and immunohistochemical analysis, we studied the possibilities of the effect of nanoCeO2 on the processes of bone tissue remodeling after surgical interventions. NanoCeO2 was placed in a new bioconstruction developed by us based on platelet-rich fibrin. Rabbits of the “Soviet Chinchilla” breed were injected with a new biocomposition with nanoCeO2 on one side of the jaw into a hole formed with a trephine and with granular xenogenic osteoplastic material on the other side. The analysis of the state of the bone tissue was carried out on days 15, 25, 35, 45, and 55. The results of the morphological analysis showed that when the defects were filled with a new bioconstruction nanoCeO2 , complete formation of bone tissue was observed, which was almost morphologically identical to the parameters of the native bone tissue. Morphometric analysis showed a high activity of the expression of matrix metalloproteinase-9 when the defects were filled with a new bioconstruction based on nanoCeO2 at all stages of observation.

Key words: bone remodelling, cerium oxide nanoparticles, periodontal surgery, platelet-rich plasma

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