Abstract

The current study was suggested for treating bacteria previously isolated from human feces and urine samples by the bioactive compounds extracted from marine origin. The three bacteria used in this study were fully identified as; Escherichia coli MK106369.1, Klebsiella pneumonia MK106370.1, and Staphylococcus aureus MK106371.1 in our previous work. There were two soft coral species, three sponge species and one mangrove species were collected and then identified according to key references. They were sponge (Negombata magnifica, Siphonochalina siphonella, and Hyrtios erectus), soft coral (Sarcophyton glaucum and Xenia macrospiculata) and mangrove (Avicennia marina). On the other side, the highest activity of crude extracts inhibited identified bacteria was recorded by those of A. marina, while, the lowest activity of crude extracts which inhibited them was recorded by S. glaucum. The minimal inhibitor concentration (MIC) values for different crude extracts ranged between 25 and 75 mgml-1. The major constituents of the potent extracts were determined by the GC-MS and they were; fatty acids (tridecanoic acid, hexadecanoic acid, pentadecanoic acid, oleanoic acid, etc.) and their esters, terpenoids, carotenoids, other compounds such as; Betulin, Cryptoflavin, Zeaxanthin, Reserpine, and Amiodarone. These findings confirm that marine origin extracts, especially from mangrove leaves, may be considered as a promising source for treating bacterial resistance to antibiotics.

Key words: Human bacteria, Marine extracts, Sponge, Soft coral, Mangrove