Home|Journals|Articles by Year

Directory for Medical Articles

Original Research

RMJ. 2022; 47(1): 112-115

Clinical efficacy of 1% metformin and alendronate intra-pocket gel in moderate localized chronic periodontitis

Mamoora Arslaan, Nasim Karim,Mehr Fatima.


Objective: To compare clinical efficacy of 1% metformin and alendronate gel in adjunct to scaling and root planning (SRP) on clinical and biochemical parameters in patients having moderate localized chronic periodontitis.
Methodology: In this randomized open label clinical trial, 60 systemically healthy, males and females aged 30-50 year, diagnosed with localized moderate chronic periodontitis were enrolled from Bahria Dental College Hospital by convenient sampling technique. Duration of study was 6 months. Participants with deepest periodontal pocket depth (PPD), clinical attachment loss (CAL), plaque index (PI) and mean sulcular bleeding index (mSBI) were included whereas those with history of periodontal therapy and mouthwashes were excluded. Patients were divided randomly into two groups each group consisting of 30 patients. Group A received Metformin 1% gel and Group B received Alendronate 1% gel, both intra-pocket with SRP at day 0. Clinical parameters were evaluated at day 0, 45 and 90. TNFα was evaluated by Eliza at day 0 and 90. Statistical analysis was done using SPSS version 23.
Results: Group A showed the significant reduction in PPD and CAL compared to group B while PI and mSBI were found non-significant. TNFα was significantly reduced in group A at day 90.
Conclusion: We found that 1% Metformin gel produced more beneficial effects in adjunct to SRP on clinical and biochemical parameters in comparison to 1% Alendronate gel.

Key words: Alendronate, chronic periodontitis, gingival crevicular fluid, Metformin, TNF-α.

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.