Objective: to evaluate the affect zinc sulphate and folic acid handling on the seminal fluid factor in patients with idiopathic male infertility.
Patients and methods: From February 2013 to February 2020, 700 patients with idiopathic primary infertility, presented to Al Yarmouk teaching hospital and Al Ramadi teaching hospital in addition to 3 private clinics were enrolled in this prospective study, their age ranged from 17 to 56 years, Semen evaluation done for all patients at the start of study (baseline) and after three months of treatment. The patients received folic acid 5 mg and zinc sulphate 60 mg prepared in special capsules once daily for 3 months.
Results: Seven hundreds patients completed the treatment period for 3 months. The age of patients raged from 17 to 56 years, there was statistically significant difference in the sperm concentration after treatment compared to baseline and also statistically significant difference in the perm motility after 3 months treatment period (p value < 0.05).The increment in the percentage of normal morphology was statistically non-significant, and also the slight increase in the seminal fluid volume was non-significant (p value > 0.05).
Conclusion: Handling of idiopathic male infertility with combination of zinc sulphate and folic acid was safe and effective in improving seminal fluid parameters.
Key words: folate, zinc, idiopathic, infertility