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The Effect of Endodontic Infection on the Pathogenesis of the Systematic Disease: A Systematic Review and Meta-analysis

Samira Jamali*, Elnaz Mousavi, Sepideh Behzadi, Golchin Jabbari, Ali Eslambol Nassaj, Ayşe Karadayi.


Objective: The results detailed that a few systemic disorders may impact endodontic healing results. A systematic review can complete such analyses to investigate endodontic infection and cardiovascular disease thoroughly. This systematic review and meta-analysis aimed to evaluate the effect of Endodontic Infections on Cardiovascular Disease.
Method: Our search strategy was to screen the relevant articles on the electronic databases of Google Scholar, MEDLINE, Cochrane Library, PubMed, ISI, and Embase, published from January 2005 to January 2020. The management of electronic titles was performed using Endnote X9 software. The main keywords for the search process included "Cardiovascular disease OR CVD", "LEO"," Endodontics", "Endodontic Infections" "dental evaluations", "missing teeth", "apical lesions", "bone loss". The current systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Results: Electronic and manual searches resulted in 53 relevant titles and abstracts. Eventually, five publications were eligible for the inclusion criteria required for this systematic review. The risk ratio (RR) was 1, and the 95% certainty interval (CI) was 3.56–15.87; the obtained very low certainty indicated that the lesion of endodontic origin (LEO) might impact Cardiovascular disease (CVD) improvement.
Conclusion: Endodontic Infection may or may not exert a few effects on the systemic Cardiovascular disease (CVD), and there was a low level of proof.

Key words: Endodontic infection, Cardiovascular disease, CVD, LEO, pathogenesis.

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