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A study on clinicopathological correlations after laparoscopic radical prostatectomy patients for high risk prostate carcinoma

Shrenik J. Shah, Prashant Patel, Narendra Singh Patel.

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AIM: To compare between clinical and pathological parameters after laparoscopic radical prostatectomy in high-risk prostate carcinoma patients
Method: A retrospective observational study had 143 high-risk prostate cancer patients of Indian origin, based on the the D’Amico classification system. The baseline workup was completed. Perioperative parameters and pathological findings were recorded. Multivariate analysis was performed to find predictive factors of pathological stage and PSM for comparison.
Results: mean age and PSA were 65.3 ± 6.3 years and 26.4 ng/ml, respectively. Biopsy GS ≥8 was present in 108 patients, and clinical stage (CS) ≤T2 was present in 76 patients. The conversion to open surgery rate was 17.4%. Mean operative time was 165 minutes; blood loss was 300 ml; hospital stay was 3.5 days; mean catheterization time was 15 days; the most common complications were hemorrhage and wound infection PSM rate was 26.57%; upstaging was in 52; downstaging was in 16 patients ; pT2 was 30.76%; pT3a was 27.97%; pT3b was 41.25%. Gleason score and clinical stage were predictive of pathological stage, and PSM was predictive of clinical stage.
Conclusions: Gleason Scores on needle biopsy and clinical stage on multiparametric MRI were predictive of pathological stage . PSM was predictive of clinical staging on multiparametric MRI in our study

Key words: High risk prostate carcinoma, laparoscopic radical prostatectomy, clinical stage, pathological stage

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