To make timely diagnosis of neurological disorders, 62 full-term newborns born to women of high perinatal and
obstetric risk were examined. In 50 newborns prospective studies were performed in the early and late neonatal
periods to determine the level of autoantibodies to the main myelin protein, which is a universal marker of
demyelination. Control group consisted of 30 healthy newborns born to mothers with a physiological course of
pregnancy and childbirth. The level of autoantibodies to the main myelin protein in the blood serum was determined
by enzyme-linked immunosorbent assay using diagnostic test systems of the "Navina" company, Moscow,
according to the manufacturer's method. A significant increase in the level of autoantibodies to the main myelin
protein was revealed both in the early and late neonatal period in children born with signs of cerebral hypoxia -
ischemia compared with children in the control group. Thus, the determination of the autoantibodies level to the
main myelin protein can serve as a highly informative screening diagnostic marker for preclinical diagnosis of
cerebral deficiency in young children with perinatal damage to the central nervous system.
newborns, children, cerebral hypoxia - ischemia, autoantibodies to the main myelin protein,
SARS-CoV-2 detection with aptamer-functionalized gold nanoparticles.
Aithal S, Mishriki S, Gupta R, Sahu RP, Botos G, Tanvir S, Hanson RW, Puri IK
Talanta. 2022; 236(): 122841
Growth differentiation factor 5: a neurotrophic factor with neuroprotective potential in Parkinson's disease.
Goulding SR, Anantha J, Collins LM, Sullivan AM, O'Keeffe GW
Neural regeneration research. 2022; 17(1): 38-44
Advancing Our Understanding of Brain Disorders: Research Using Postmortem Brain Tissue.
Curtis MA, Vedam-Mai V
Methods in molecular biology (Clifton, N.J.). 2022; 2389(): 201-208
Optogenetic activation of intracellular signaling based on light-inducible protein-protein homo-interactions.
Huang P, Zhao Z, Duan L
Neural regeneration research. 2022; 17(1): 25-30
A neuron's ambrosia: non-autonomous unfolded protein response of the endoplasmic reticulum promotes lifespan.
Homentcovschi S, Higuchi-Sanabria R
Neural regeneration research. 2022; 17(2): 309-310