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Research Article

JCR. 2020; 7(9): 1915-1921


THE ROLE OF MYELINATION PROCESS DISORDERS IN THE MECHANISMS OF CEREBRALHYPOXICISCHEMIC DAMAGE FORMATION OF THE CENTRAL NERVOUS SYSTEM IN NEWBORNS FROMHIGH PERINATAL RISK GROUPS

Sofia B. Berezhanskaya, Diana I. Sozaeva, Alexander A. Afonin, Irina V. Panova, Zoya A. Goncharova, Elena A.Lukianova.

Abstract
To make timely diagnosis of neurological disorders, 62 full-term newborns born to women of high perinatal and
obstetric risk were examined. In 50 newborns prospective studies were performed in the early and late neonatal
periods to determine the level of autoantibodies to the main myelin protein, which is a universal marker of
demyelination. Control group consisted of 30 healthy newborns born to mothers with a physiological course of
pregnancy and childbirth. The level of autoantibodies to the main myelin protein in the blood serum was determined
by enzyme-linked immunosorbent assay using diagnostic test systems of the "Navina" company, Moscow,
according to the manufacturer's method. A significant increase in the level of autoantibodies to the main myelin
protein was revealed both in the early and late neonatal period in children born with signs of cerebral hypoxia -
ischemia compared with children in the control group. Thus, the determination of the autoantibodies level to the
main myelin protein can serve as a highly informative screening diagnostic marker for preclinical diagnosis of
cerebral deficiency in young children with perinatal damage to the central nervous system.

Key words: newborns, children, cerebral hypoxia - ischemia, autoantibodies to the main myelin protein, neuroimmune disorders



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