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A comparative study on the renal function parameters and serum C reactive protein levels in relation to the severity of preeclampsia

Shimna C S, Jean Maliekkal, Geetha N, Atmaja Nair.


Background: Preeclampsia is one of the major complications affecting the pregnancy. It is an important cause of both maternal and fetal morbidity and mortality worldwide.

Aims and Objectives: The aim of the study was to assess the renal function and serum C reactive protein (CRP) levels in pre-eclampsia.

Materials and Methods: Our study was a cross-sectional study conducted among 90 pregnant women in a tertiary care center in Kerala. The Institutional Ethics Committee approved the study. Blood urea, serum creatinine, and serum CRP levels were estimated in 30 normotensive pregnant women, 30 mild preeclamptic, and 30 severe pre eclamptic women. Statistical analysis was done.

Results: The mean values of all the three parameters were highest in severe pre-eclampsia when compared to the normotensive pregnant women. The mean values in mild pre-eclampsia lies in between the values of other two groups. The results were statistically significant.

Conclusion: Significant alteration in renal function tests and serum CRP levels prove to be an important indicator in assessing the severity of preeclampsia.

Key words: Preeclampsia; C-Reactive Protein; Blood Urea; Pregnancy

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