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Original Research

Natl J Med Res. 2020; 10(2): 89-93


Ventilator-associated pneumonia in a tertiary care intensive care unit: Analysis of incidence,microbiological profile,resistant pattern and outcome

Sandeep Kumar, Malay Sarkar, D V Singh, R S Negi, Sunil Sharma, Sanjeev Prabhakar.


Abstract

Abstract Background:
Ventilator-associated pneumonia (VAP) is the most common nosocomial infection diagnosed in the intensive care unit (ICU).
Aims:
The aim is to determine the incidence, bacteriology and resistant pattern and 28 days mortality in intensive care unit.
Material and Methods:
This prospective study was conducted in intensive care unitfrom July 2017 through June 2018 . All the patients who were on mechanical ventilation for >48 h in the ICU during the study period were enrolled. VAP was diagnosed according to the Centre for Disease Control (CDC) criteria.
Statistical Analysis:
Fisher's exact test was applied to compare two or more set of variables.P-value less than 0.05 was considered to be statistically significant.
Results: A total of 117 patients were included in the study and VAP developed in 49 patients with an incidence of VAP 0.42 % episodes of infection/1000 mechanical ventilation days( 95% Confidence Interval: 0.32 to 0.514).These were predominantly caused by Gram-negative organisms and the most common organism isolated was Acinetobacter baumanii(12 isolates, 40%). Acinetobacter baumanii infection was associated with prolonged ICU stay(P value 0. 009).Colistin was the most effective drug in our study and found to be effective in >90% of the patients. The overall mortality of VAP patients in our study was 36.7%. Patients with underlying diabetes mellitus and hypertension had adverse outcome in comparison to the patients without underlying comorbidity (P value=0.017). Conclusions: VAP continues to be a major threat to patients who are admitted for mechanical ventilation into the critical care unit, emphasizing the urgent need for infection control measures.

Key words: ventilator associated pneumonia,Acinetobacter baumannii, colistin






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