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SRP. 2021; 12(2): 159-164

The Influence of Togetherness of Herpetic Virus infections on Cell Cycle Regulatory Gene Expressions in Sinonasal Malignancy

Marwa M. A. Jassim, Fakhria A. Al-Joufi, Majid M. Mahmood, Saad H. M. Ali, Gheed Matlub, Imad M. Al-Ani, Hassan A. Elgebaly, Ayman M. Mahmoud.


The Epstein-Barr virus (EBV) is categorized as a human gamma-1 herpes-virus. The EBV infection can increase the risk of developing certain rare cancers such as sinonasal carcinomas (SNC). That due to the powerful ability of EBV to cause mutations in the cells and make cancerous changes in the tissues. The human cytomegalovirus (HCMV), mainly in tumor tissues, can target different types of cells. In addition, it can cause all hallmarks of cancerous changes in the tissues which is considered as a defining feature of these pathogens. The HCMV strictly exhibits both of cellular tumor-promoting and immune-evasive strategies as well. However, the p27(Kip1) protein, might contribute in many different signal transduction pathways and modulate the intermediate oncogenic roles in cancer. The p27(Kip1) protein combines with cyclin E-CDK2, cyclin A-CDK2, and cyclin D1-CDK4 forming complexes, resulting in preventing their activation. Mitogenic signals that cause reduction of p27 expression allow activation and progression of CDK/cyclin in the cell cycle. The p73 is a protein related to the p53 tumor protein; it considered as tumor suppressor that is significantly involved in the regulation of cell cycle and induction of apoptosis. This study aim at investigating the effect of both the HCMV and EBV infections on the gene expression of both p 27 and p73 in sinonasal carcinomas (SNC). The study involved eighteen (18) formalin-fixed, paraffin-embedded tissue blocks of sinonasal carcinomas (SNC). The verificatory re-examination for histopathological samples was done. The EBV-EBERs and HCMV-PP65 DNA localization detected by a Chromogenic In Situ Hybridization technique (CISH), while p27 and p73 gene product detected by immunohistochemistry technique (IHC). From the recent data, it is clear that the existence of those two viruses in SNC were at the highest range in poor different grades (45.5%). On the contrary, the co-expression rate of p27 and p73 genes were at elevated in poorly differentiated SNC tissues (73.5%).


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