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Evaluation of plasma levels of homocysteine in patients of coronary artery disease in various age groups

Vanita Bansal, Arti Gupta, Sanjeev Mahajan, Arshdeep Kaur.




Abstract

Background: Coronary artery disease (CAD) also known as ischemic heart disease is the most common form of cardiovascular disease. In CAD, there is an inadequate supply of blood and oxygen to a portion of the myocardium. Early screening, diagnosis, and risk assessment of coronary heart disease are of great importance for its prevention, treatment, and prognosis. Hyperhomocysteinemia can cause increased oxidation of low-density lipoprotein, which can lead to increased free radical formation which in turn causes endothelial injury thus initiating the process of atherosclerosis and finally leads to CAD.

Aim and Objectives: The aim of the study was (1) to evaluate levels of total homocysteine (Hcy) CAD patients and (2) to evaluate levels of Hcy in various age groups.

Materials and Methods: The proposed observational and comparative study was conducted in the Government Hospital, Amritsar. Data collection was done using semi structure questionnaire. Selection of the study group was done using inclusion and exclusion criteria. The study group included 40 patients of age group 30–80 years, clinically diagnosed as patients of CAD. The study was conducted at Govt. Medical College Amritsar.

Results: It is concluded that increase Hcy levels are associated with CAD.

Conclusions: CAD is found to be associated with high Hcy levels. Early assessment of risk factors and lifestyle modifications has important role in diagnosis and prevention of CAD.

Key words: Coronary artery disease; Endothelial Derived Relaxation Factor; Homocysteine Levels; Multifactorial






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