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Research Article

JCDR. 2022; 13(1): 937-943


Carotid intima-media thickness (CIMT) as marker of subclinical atherosclerosis in chronic obstructive pulmonary disease (COPD)

Dr Man Mohan Puri, Dr Ravi Kumar Sharma, Dr DeveshChauhan, Dr Umesh Kumar Pandey, Dr RavitaKumari.


Abstract

Objectives: The present study was done with the objectives to evaluate the changes of
carotid intima-media thickness (CIMT) in patients suffering from COPD and tosee the
correlation between the CIMT and various stages of COPD.
Methods: Single centre, prospective, observational study of 31 COPD patients. Measurement
of Carotid intima media thickness (IMT) was done by carotid Doppler ultrasound from both
common carotid arteries. Data obtained was analyzed using Microsoft Excel, SPSS (v 20).
Pearson correlation coefficient (R) calculated for correlation among variables. Statistical
significance was accepted at the level of P < 0.05.
Results: The mean CIMT in study population was 1.42 mm (0.4-3.4 mm, ±0.76). CIMT
scores increases with increasing COPD (GOLD) stage. Mean CIMT values in COPD GOLD
stage 1,2,3,4 were 0.84 mm, 1.21 mm, 1.41 mm, and 1.67 mm respectively. In COPD
patients CIMT values had a significant negative correlation with FEV1and FEV1/FVC ratio.
Conclusions:CIMT measurement may be an important non-invasive assessment tool to
measure atherosclerosis burden in COPD patients. As the disease severity advances CIMT
values also increases, reflecting higher plaque burden. CIMT values can be used to guide
further cardiovascular evaluation and management in COPD patients to avoid cardiovascular
morbidity and mortality.

Key words: Common carotid artery, Chronic obstructive pulmonary disease, Doppler Ultasonography, intima-media thickness.






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