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Research Article

JCDR. 2022; 13(2): 12-20

Safety and Efficacy of Transdermal Buprenorphine Versus Oral Tramadol for Treatment of Post-Operative Pain Following Lower Limb Surgery

Burulukui Hembram, Subir Kumar Brahma, Pradip Kumar Mandal, Salman Hussen.


Background: Patients who have undergone lower limb surgery are vulnerable to adverse
consequences from unrelieved or undertreated postoperative pain after surgery. Tramadol has
a broad range of therapeutic indications, from acute to chronic pain, and has been used as a
first-line treatment in musculoskeletal system disorders, for relief of persistent postoperative
pain, as well as various types of chronic pain. Buprenorphine is a synthetic opioid analgesic
used in the management of postoperative pain. Material and Methods: This is a prospective
and single center study conducted at Orthopaedic operation theatre, General surgery
operation theatre, post anesthetic unit, post-operative ward of Tertiary care teaching Hospital
over a period of 1 year. Total no of patients were 50, they were allocated as follows. Group
A-those who received transdermal buprenorphine 10 micro gm/hr (TDB GROUP). Group Bthose
who received oral tramadol (50 mg) twice daily (OT GROUP). Results: In group-OT,
the mean duration of surgery (mean±s.d.) of patients was 118.6800 ± 22.9542 min. In group-
TDB, the mean duration of surgery (mean±s.d.) of patients was 129.1200 ± 22.7529 min.
Distribution of mean duration of surgery vs. group was not statistically significant
(p=0.1128). In group-OT, 14(56.0%) patients had ASA I and 11(44.0%) patients had ASA II.
In group-TDB, 11(44.0%) patients had ASA I and 6(24.0%) patients had ASA II. Association
of ASA vs. group was not statistically significant (p=0.1355). Conclusion: It was found that
mean VAS at 24 hr, was significantly lower in transdermal buprenorphine compared to oral
tramadol. It was found that mean HR at 24 hr in oral tramadol group was significantly higher
than transdermal buprenorphine and that mean post op pain was more in oral tramadol group
than transdermal buprenorphine group.

Key words: Transdermal, Buprenorphine, Lower Limb Surgery

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