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Research Article

JCDR. 2022; 13(2): 6-11


A Study to Compare the Changes on Haematological Parameters in Obese Subjectswith Insulin Resistance and Non-Obese Subjects

Anant Prakash Pandey, Sharan B Singh M.


Abstract

Background:Insulin resistance is a decreased biological response to normal levels of
circulating insulin. Decrease in insulin response causes increased stimulation of beta cell as a
compensatory mechanism resulting in hyperinsulinemia.Insulin resistance is related with
genetic susceptibility and obesity. Aim: The present study was planned to study the
relationship between insulin resistance and haematological parameters in obese
populationMaterial and Methods:The subjects selected are 83 in number with age group 30
to 50 years of both the sex and they are grouped into 50 control (non-obese) subjects were
free from insulin resistance and 33 cases (obese) subjects having insuin resistance. In all the
subjects we have measured height and weight, and calculated body mass index.We have also
collected fasting blood samples and measured fasting plasma glucose and fasting plasma
insulin. Insulin resistance in the subjects was calculated by homeostasis model assessment
index (HOMA-IR) and haematological parameters such as red blood cell counts,
haemoglobin concentration, haematocrit value, total leucocyte count, platelet count and
fibrinogen level estimated in all the subjects.Results &Conclusion:The means are compared
using student’s ‘t’ test and proportion compared using chi-sqare test. We found increased red
blood cell count (p=0.0001), haemoglobin concentration (p=0.0001), haematocrit value
(p=0.0001), total leucocyte count (p=0.0001) and platelet count (p=0.0001), and these values
were statistically significant (p

Key words: Body mass index, Insulin Resistance, Homeostasis model assessment (HOMA).






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