Abstract
The spectrum of resistant to antibiotics by Klebsiella pneumoniae is gradually increasing. This study was undertaken to detect Multidrug Resistance (MDR), Extensive Drug Resistance (XDR) and Pan-drug Resistance (PDR) Klebsiella pneumoniae in patients attending general hospital, Azare Bauchi state Nigeria. An antimicrobial sensitivity test was carried out to detect the susceptibility of Klebsiella pneumoniae to different classes of antibiotics as recommended by CLSI guideline. The pattern of resistant to Gentamycin,Streptomycin, Amoxicillin, Penicillin, Rocephin, Tetracycline, Oxytetracycline, Tetracycline, Ciprofloxacin, Levofloxacin, Ofloxacin,and Erythromycin from Fluoroquinolones, Beta-Lactams, Aminoglycoside,and Macrolite determine the MDR, XDR,and PDR of the test bacteria. Fifty-two (52) bacterial isolate were identified from 60 urine samples, Klebsiella pneumoniae recorded highest occurrences rate with 32 (61.5%) followed by Escherichia coli 8(15.4%), Staphylococcus aureus 7(13.5%) then Streptococcus species 5(9.6%). However, the identified isolates were higher in male patients with 30(69.7%) and 22 (42.3%) in female patients out of 52(100%).Amoxicillin and penicillin were resistant to Beta-lactam with 12 mm and 10 mm zone of inhibition, Levofloxacin is resistant to Fluoroquinoloneswith 5 mm zone of inhibition, Gentamycin and Streptomycin were resistant to Aminoglycoside were with 8mm and 2mm zone of inhibition and Erythromycin is resistant to Macrolite with 8 mm zone of inhibition. K. pneumoniae resistant to almost all classes of antibiotics were recorded, further research should be conducted hypervirulent strain to compare virulence with resistivity.
Key words: Klebsiella pneumonia, MDR, EDR, PDR.
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