The zileuton was determined utilizing the differential pulse voltammetry (DPV) approach employing a modified molecularly imprinted carbon paste electrode (CPE) containing BiOCl/CuS@SnO2NPs nanocomposite The BiOCl/CuS@SnO2NPs/CPE exhibits a strong and well-defined peak for the oxidation of zileuton at 640 mV in phosphate buffer solution pH = 8. With a linear range of 4-75 µM and a low detection limit of 0.0.7 µM, DPV was used to measure zileuton. BiOCl/CuS@SnO2NPs/CPE was tested for repeatability, reproducibility, and stability, and the results support the sensor's good characteristics. The selectivity of the proposed method was studied, and the results showed that there was no disruption in the detection of zileuton, and that the peak current changed by less than 5%. Finally, BiOCl/CuS@SnO2NPs/CPE was successfully used to determine zileuton in pharmaceutical formulations and human serum samples, with recovery rates ranging from 98.3% percent to 103.6% percent and an RSD of less than 5%.
Key words: Nanocomposite, Zileuton, Carbon Paste Electrode, modified.
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