We aimed to show whether insufficiency develops in pancreatic exocrine functions since the insulin resistance period or not. We measured the anthropometric parameters, blood glucose profile parameters and fecal elastase-1 (FE-1) levels of a total of 65 obese patients with 35 insulin resistance and 30 without insulin resistance. Body mass indexes (BMI) and homeostasis of model assessment insulin resistance indexes (HOMA-IR) were calculated. Exocrine pancreatic insufficiency (EPI) was diagnosed with a FE-1of less than 200 mg/g (ELISA). A statistically significant difference was not observed between the mean FE-1 levels between the groups (p> 0.05). No statistically significant difference was observed between the distribution of mild and severe low FE-1 levels of the insulin resistant (IR) and Non-IR groups (p> 0.05). Our study revealed that the presence of insulin resistance does not cause any change in FE-1 levels in obese patients.
Key words: Pancreatic exocrine function, insulin resistance, fecal elastase-1
|
