Objective: Obesity is an important health problem, which affects children and adolescents and is highly prevalent throughout the world. Non-alcoholic fatty liver disease is liver fattening that occurs due to non-alcohol causes, and it is associated with obesity in most of the cases. We aimed to evaluate the relation of mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR) to hepatosteatosis in obese children in our study.
Material and Methods: A total of 104 obese children aged between 4-16 years, who were determined to have a body mass index (BMI) of 95th percentile or higher according to age and gender, were examined retrospectively. The genders, ages, and examination findings of the patients were recorded. In obese children, leukocyte, hemoglobin, platelet, mean platelet volume, neutrophil and lymphocyte levels were assessed in the complete blood count performed during the first application. Neutrophil-to-lymphocyte ratio was calculated. Fasting blood glucose (FBG) and fasting insulin, serum aminotransferase values and ultrasonographic results of the patients were recorded.
Results: Hepatosteatosis was determined in 64 of 104 patients (61.53%) while it was not determined in 40 patients (38.47%). The BMI, fasting insulin, HOMA-IR, and ALT levels were higher in patients with hepatosteatosis than in the group without hepatosteatosis. The average MPV of the group with hepatosteatosis was 7.78±1.57, and the average MPV of the group without hepatosteatosis was 7.42±1.43, and no statistically significant difference was observed between the groups in terms of the average MPV (p=0.236). The average NLR was 1.62±1.06 in the group with hepatosteatosis and 1.38±0.59 in the group without hepatosteatosis. There was no statistically significant difference between the NLR averages of the groups with and without hepatosteatosis (p=0.200).
Conclusion: In the present study, no relation was determined between MPV and NLR and liver fattening in obese children.
Key words: Child, hepatosteatosis, obesity, neutrophil-to-lymphocyte ratio, mean platelet volume
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